Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682285 | 1.00 | LMNA (0.52) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL8416364 | 0.80 | AKR1C3 (0.59) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL7525200 | 0.80 | AKR1C3 (0.59) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL6462299 | 0.78 | CYP1A2 (0.50) | KMT2AMEN1AKR1C3 | |
| SCHEMBL5560121 | 0.78 | ALDH1A1 (0.47) | LMNAKMT2AMEN1TDP1AKR1C3 | |
| Ortho-Phthalaldehyde SCHEMBL5968146 | 0.78 | LMNA (0.77) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL10620495 | 0.75 | LMNA (0.56) | LMNAKMT2AMEN1THRBBLM | |
| Ortho-Phthalaldehyde SCHEMBL28379746 | 0.75 | LMNA (0.93) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL6455663 | 0.74 | LMNA (0.60) | LMNAKMT2AMEN1TDP1 | |
| SCHEMBL1804114 | 0.74 | AKR1C3 (0.61) | LMNAKMT2AMEN1TBXAS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| US-5091395-A | Hypotensive agents | GLAXO S.P.A. (IT) | 1992-02-25 | — | — | US | disclosed |
| EP-0226271-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |