Sulfuric Acid

Sulfuric Acid

SCHEMBL9682447

COCCNc1ccc(N)cc1OC.O=S(=O)(O)O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO

The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 3/20 0.49
MAPT P10636 5/20 0.45
GAA P10253 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
HTT P42858 1/20 0.41
HCAR3 P49019 1/20 0.40
NCF1 P14598 1/20 0.39
USP2 O75604 1/20 0.39
LMNA P02545 3/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9499986 0.91 PTGER4 (0.49) PTGER4MAPTGAASMN1; SMN2NPC1
Sulfuric Acid SCHEMBL9680698 0.87 GAA (0.43) MAPTGAASMN1; SMN2NPC1RAB9A
Sulfuric Acid SCHEMBL9681916 0.83 PTGER4 (0.49) PTGER4MAPTGAASMN1; SMN2ALDH1A1
SCHEMBL9499966 0.79 GAA (0.47) MAPTGAASMN1; SMN2NPC1RAB9A
SCHEMBL25091235 0.76 MAPT (0.51) MAPTGAASMN1; SMN2NPC1RAB9A
SCHEMBL14243078 0.75 CHRM2 (0.48) MAPTGAATSHRMAPK1HTT
SCHEMBL11311817 0.74 PTGER4 (0.50) PTGER4MAPTRAB9AALDH1A1HTT
SCHEMBL9499759 0.74 PTGER4 (0.50) PTGER4MAPTGAASMN1; SMN2ALDH1A1
SCHEMBL3234161 0.74 LMNA (0.49) MAPTGAASMN1; SMN2NPC1RAB9A
SCHEMBL6572270 0.74 ALDH1A1 (0.50) PTGER4MAPTNPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5167669-A Hair dyes L'OREAL (FR) 1992-12-01 US disclosed
US-5096455-A PROCESS FOR DYEING KERATINOUS FIBRES EMPLOYING AN INDOLE DYE AND AT LEAST ONE PARA-PHENYLENEDIAMINE CONTAINING A SECONDARY AMINO GROUP ABSENT AN OXIDANT OTHER THAN AIR L'OREAL (FR) 1992-03-17 US disclosed