Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682084 | 0.98 | MAPT (0.36) | NPC1MAPTPOLBNPSR1RXFP1 | |
| SCHEMBL9681437 | 0.86 | NPSR1 (0.34) | NPC1MAPTNPSR1RXFP1KDM4E | |
| SCHEMBL9846183 | 0.85 | RXFP1 (0.38) | NPC1MAPTPOLBNPSR1RXFP1 | |
| SCHEMBL9680861 | 0.85 | SLC2A1 (0.38) | MAPTPOLBKDM4EAPAF1RECQL | |
| SCHEMBL9680321 | 0.84 | NPSR1 (0.36) | NPC1MAPTPOLBNPSR1RXFP1 | |
| SCHEMBL9680359 | 0.82 | MAPT (0.34) | MAPTKDM4EAPAF1RECQL | |
| SCHEMBL9682064 | 0.82 | MAPT (0.34) | MAPTKDM4EAPAF1RECQLP2RX7 | |
| SCHEMBL9681442 | 0.80 | KDM4E (0.36) | MAPTKDM4EAPAF1RECQL | |
| SCHEMBL9681915 | 0.79 | PDE10A (0.40) | NPC1MAPTKDM4EAPAF1RECQL | |
| SCHEMBL9682808 | 0.78 | PDE10A (0.34) | MAPTPOLBKDM4EAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | claimed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |