Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | XPO1 | O14980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968297 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL4553471 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL4554759 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL963702 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL962500 | 0.81 | L3MBTL1 (0.50) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL962501 | 0.81 | L3MBTL1 (0.50) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL964782 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL964785 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL962581 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL962582 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNR2F2HTTMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-01-13 | — | — | US | disclosed |
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |
| US-20080194617-A1 | Fused ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194617-A1 | Fused ring compound | SLC5A1, SLC5A2, GPR119 | SMN1; SMN2 3745/4885MAPT 4343/4885NR2F2 2010/4885 |
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | PPARA, PPARD, PPARG | SMN1; SMN2 4710/4885MAPT 4720/4885NR2F2 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.