Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554759 | 0.98 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTNR2F2HTTCYP1A2 | |
| SCHEMBL963702 | 0.88 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTNR2F2HTTCYP1A2 | |
| SCHEMBL4553594 | 0.86 | KDM4E (0.35) | MAPTHTR2AHTR2CMEN1KMT2A | |
| SCHEMBL4565958 | 0.85 | ROCK1 (0.41) | SMN1; SMN2MAPTHTR2CPDGFRBL3MBTL1 | |
| SCHEMBL964782 | 0.84 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTNR2F2HTTCYP1A2 | |
| SCHEMBL962500 | 0.84 | L3MBTL1 (0.50) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL964785 | 0.84 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTNR2F2HTTCYP1A2 | |
| SCHEMBL962501 | 0.84 | L3MBTL1 (0.50) | SMN1; SMN2MAPTNR2F2HTTMAPK8 | |
| SCHEMBL4553928 | 0.83 | CA12 (0.35) | SMN1; SMN2MAPTHTTCYP1A2CYP2C9 | |
| SCHEMBL968297 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTNR2F2HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |