Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375917 | 0.79 | NPSR1 (0.45) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL6382584 | 0.79 | NPSR1 (0.45) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL31478620 | 0.77 | F2 (0.40) | NPSR1KDM4EALDH1A1NR4A2GAA | |
| SCHEMBL6380750 | 0.76 | NPSR1 (0.41) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL17429945 | 0.72 | MAPK1 (0.39) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL388845 | 0.69 | NPSR1 (0.50) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL30570809 | 0.69 | NPSR1 (0.56) | NPSR1KDM4EALDH1A1KDM4CSTAT3 | |
| SCHEMBL5747714 | 0.69 | NPSR1 (0.50) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL29829085 | 0.69 | NPSR1 (0.50) | NPSR1ERCC1FEN1ERCC4KDM4E | |
| SCHEMBL27989922 | 0.69 | SLC22A6 (0.36) | ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102603657-B | Preparation method of 6-bromine-3-hydroxyl-2-pyrazinamide | SHANDONG QIDU PHARMACEUTICAL | 2015-02-04 | — | — | CN | claimed |
| US-12528778-B2 | Microbiocidal derivatives | SYNGENTA CROP PROTECTION AG (CH) | 2026-01-20 | — | — | US | disclosed |
| US-12371428-B2 | Pyridone compounds and methods of use | EXELIXIS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| CN-113924294-B | Microbiocidal derivatives | 先正达农作物保护股份公司 | 2024-12-06 | — | — | CN | disclosed |
| EP-3976601-B1 | MICROBIOCIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2024-02-28 | — | — | EP | disclosed |
| US-20230192628-A1 | MICROBIOCIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2023-06-22 | — | — | US | disclosed |
| US-20220315579-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS, INC. | 2022-10-06 | — | — | US | disclosed |
| EP-4034532-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE | Exelixis, Inc. (US) | 2022-08-03 | — | — | EP | disclosed |
| CN-114787144-A | Pyridone compounds and methods for modulating protein kinases | 埃克塞里艾克西斯公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113924294-A | Microbicidal derivatives | 先正达农作物保护股份公司 | 2022-01-11 | — | — | CN | disclosed |
| WO-2021062245-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE | EXELIXIS, INC. (US) | 2021-04-01 | — | — | WO | disclosed |
| WO-2020239853-A1 | MICROBIOCIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2020-12-03 | — | — | WO | disclosed |
| CN-102603657-B | Preparation method of 6-bromine-3-hydroxyl-2-pyrazinamide | SHANDONG QIDU PHARMACEUTICAL | 2015-02-04 | — | — | CN | disclosed |
| CN-102603657-A | Preparation method of 6-bromine-3-hydroxyl-2-pyrazinamide | SHANDONG QIDU PHARMACEUTICAL | 2012-07-25 | — | — | CN | disclosed |
| US-5079251-A | Insecticides, pesticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-01-07 | — | — | US | disclosed |
| EP-0408196-A2 | Pyrazinone derivatives as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12371428-B2 | Pyridone compounds and methods of use | PDXK, PLK2, MAP4K2 | NPSR1 4208/4885ERCC1 1583/4885FEN1 1136/4885 |
| US-12528778-B2 | Microbiocidal derivatives | CCR1, CCR6, CCRL2 | NPSR1 1873/4885ERCC1 132/4885FEN1 774/4885 |
| US-20230192628-A1 | MICROBIOCIDAL DERIVATIVES | MPO, PRF1, MSR1 | NPSR1 2130/4885ERCC1 1556/4885FEN1 947/4885 |
| US-20220315579-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | PDXK, PLK2, MAP4K2 | NPSR1 4208/4885ERCC1 1583/4885FEN1 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.