Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.53 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 8/20 | 0.52 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683086 | 0.88 | TBXA2R (0.68) | MAPTLMNATP53ALDH1A2ALDH1A1 | |
| SCHEMBL9681793 | 0.88 | TBXA2R (0.67) | MAPTLMNATP53POLBTBXA2R | |
| SCHEMBL9681443 | 0.85 | TBXA2R (0.61) | TBXA2R | |
| SCHEMBL9683508 | 0.84 | TBXA2R (0.62) | LMNAALDH1A1TBXA2RNPSR1 | |
| SCHEMBL9683313 | 0.84 | TBXA2R (0.64) | MAPTLMNATP53TBXA2RPPARG | |
| SCHEMBL9683131 | 0.83 | TBXA2R (0.76) | ALDH1A1TBXA2R | |
| SCHEMBL9682437 | 0.82 | TBXA2R (0.76) | LMNATBXA2RMEN1KMT2ANPSR1 | |
| SCHEMBL9681897 | 0.81 | TBXA2R (0.78) | MAPTLMNATP53ALDH1A1TBXA2R | |
| SCHEMBL9681901 | 0.78 | TBXA2R (0.62) | TBXA2R | |
| SCHEMBL9682995 | 0.78 | TBXA2R (0.78) | TBXA2RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |