Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683115 | 0.86 | TBXA2R (0.63) | TBXA2RDRD2NOD1GALR3NR2F2 | |
| SCHEMBL9683131 | 0.80 | TBXA2R (0.76) | TBXA2RDRD2GALR3NR2F2RAB9A | |
| SCHEMBL9683051 | 0.79 | TBXA2R (0.78) | TBXA2RDRD2NOD1GALR3NR2F2 | |
| SCHEMBL13508736 | 0.79 | ALOX5AP (0.66) | TBXA2RDRD2NOD1GALR3NR2F2 | |
| SCHEMBL9681424 | 0.78 | TBXA2R (0.59) | TBXA2RDRD2NOD1GALR3NR2F2 | |
| SCHEMBL9683004 | 0.78 | TBXA2R (0.64) | TBXA2RDRD2NOD1GALR3NR2F2 | |
| SCHEMBL17380973 | 0.77 | POLB (0.58) | RAB9AKDM4EALDH1A1MAPTTP53 | |
| SCHEMBL28445360 | 0.76 | MAPT (0.48) | NOD1KDM4EALDH1A1NOD2MAPT | |
| SCHEMBL945578 | 0.75 | POLB (0.61) | MAPTTP53AGTR1AGTR2LMNA | |
| SCHEMBL9777414 | 0.75 | GALR3 (0.50) | TBXA2RDRD2NOD1GALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |