Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 4/20 | 0.63 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683113 | 0.86 | TBXA2R (0.54) | TBXA2RNOD1MAPTDRD2KDM4E | |
| SCHEMBL13508736 | 0.83 | ALOX5AP (0.66) | TBXA2RNOD1MAPTDRD2NOD2 | |
| SCHEMBL13508737 | 0.78 | NOD1 (0.67) | TBXA2RNOD1MAPTDRD2KDM4E | |
| SCHEMBL9681794 | 0.77 | TBXA2R (1.00) | TBXA2R | |
| Clemizole SCHEMBL19976090 | 0.77 | HIF1A (0.79) | MAPTALDH1A1HIF1ATDP1NR1I2 | |
| SCHEMBL10443370 | 0.76 | PPARG (0.57) | MAPTALDH1A1RAB9ALMNAAGTR1 | |
| Clemizole SCHEMBL19976076 | 0.76 | HIF1A (0.77) | MAPTALDH1A1HIF1ATDP1NR1I2 | |
| SCHEMBL8366844 | 0.76 | RAB9A (0.76) | TBXA2RNOD1MAPTDRD2NOD2 | |
| SCHEMBL15568414 | 0.76 | MEN1 (0.76) | MAPTALDH1A1RAB9ALMNACYP1A2 | |
| SCHEMBL13186949 | 0.76 | HIF1A (0.67) | TBXA2RNOD1MAPTDRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |