Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | TSPO | P30536 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699186 | 0.87 | TP53 (0.54) | TBXA2RDRD2MAPTAGTR1AGTR2 | |
| SCHEMBL9683183 | 0.87 | MAPT (0.62) | TBXA2RDRD2MAPTAGTR1AGTR2 | |
| SCHEMBL9581584 | 0.86 | TBXA2R (0.64) | TBXA2RAGTR1AGTR2PPARG | |
| SCHEMBL9682037 | 0.86 | RXFP1 (0.44) | TBXA2RDRD2MAPTAGTR1AGTR2 | |
| SCHEMBL9700220 | 0.85 | MAPT (0.56) | TBXA2RMAPTTP53ALDH1A1 | |
| SCHEMBL9682469 | 0.81 | TBXA2R (0.62) | TBXA2RAGTR1AGTR2PPARG | |
| SCHEMBL9699171 | 0.81 | AGTR1 (0.59) | TBXA2RDRD2MAPTAGTR1AGTR2 | |
| SCHEMBL9683113 | 0.78 | TBXA2R (0.54) | TBXA2RDRD2MAPTAGTR1AGTR2 | |
| SCHEMBL9777414 | 0.78 | GALR3 (0.50) | TBXA2RDRD2TP53GALR3NR2F2 | |
| SCHEMBL9683131 | 0.76 | TBXA2R (0.76) | TBXA2RDRD2GALR3NR2F2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |