Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 7/20 | 0.67 |
| ▸ | APP | P05067 | 5/20 | 0.65 |
| ▸ | CCR5 | P51681 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | TTR | P02766 | 2/20 | 0.57 |
| ▸ | MMP1 | P03956 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | APEX1 | P27695 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848008 | 1.00 | IAPP (0.67) | IAPPAPPCCR5KDM4EMAPT | |
| SCHEMBL8741652 | 0.89 | APP (0.57) | IAPPAPPCCR5KDM4EMAPT | |
| SCHEMBL8741647 | 0.89 | APP (0.57) | IAPPAPPCCR5KDM4EMAPT | |
| SCHEMBL30449722 | 0.88 | ALOX5 (0.67) | IAPPAPPCCR5KDM4EMAPT | |
| SCHEMBL4545217 | 0.88 | ALOX5 (0.67) | IAPPAPPCCR5KDM4EMAPT | |
| Caffeic Acid SCHEMBL27469970 | 0.85 | KDM4E (0.69) | IAPPAPPKDM4EMAPTHSD17B10 | |
| Didemethylcurcumin SCHEMBL613667 | 0.83 | IAPP (0.77) | IAPPAPPKDM4EMAPTHSD17B10 | |
| Didemethylcurcumin SCHEMBL613666 | 0.83 | IAPP (0.77) | IAPPAPPKDM4EMAPTHSD17B10 | |
| SCHEMBL29565624 | 0.82 | APP (0.55) | IAPPAPPKDM4EMAPTHSD17B10 | |
| SCHEMBL13310702 | 0.82 | CA12 (0.53) | IAPPAPPCCR5KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466198-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0466197-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0464859-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-08 | — | — | EP | disclosed |
| EP-0464858-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4733002-A | Lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1988-03-22 | — | — | US | disclosed |