Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.77 |
| ▸ | APP | P05067 | 6/20 | 0.69 |
| ▸ | BACE1 | P56817 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.69 |
| ▸ | TTR | P02766 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.69 |
| ▸ | CA12 | O43570 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CA1 | P00915 | 2/20 | 0.69 |
| ▸ | CA2 | P00918 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | CA3 | P07451 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Didemethylcurcumin SCHEMBL613666 | 1.00 | IAPP (0.77) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL29565303 | 0.93 | AKR1B1 (0.76) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL3671201 | 0.93 | AKR1B1 (0.76) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL3671196 | 0.93 | AKR1B1 (0.76) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL23242792 | 0.91 | IAPP (0.66) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL4005096 | 0.91 | IAPP (0.71) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL31297169 | 0.91 | IAPP (0.66) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL4005087 | 0.91 | IAPP (0.71) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL16881737 | 0.90 | IAPP (0.69) | IAPPAPPBACE1HSD17B10MAPT | |
| SCHEMBL13810759 | 0.88 | IAPP (0.67) | IAPPAPPBACE1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119661342-A | Curcumin derivative and preparation method thereof, nano-composite and preparation method and application thereof | 湖南中医药大学 | 2025-03-21 | — | — | CN | claimed |
| US-9233263-B2 | Photoprotector and/or photoimmunoprotector compositions of the skin and their uses | INDUSTRIAL FARMACEUTICA CANTABRIA, S.A. (ES) | 2016-01-12 | — | — | US | claimed |
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | claimed |
| US-20120039828-A1 | Photoprotector and/or photoimmunoprotector compositions of the skin and their uses | Industrial Framaceutica Cantabria, S.A. (ES) | 2012-02-16 | — | — | US | claimed |
| CN-119661342-A | Curcumin derivative and preparation method thereof, nano-composite and preparation method and application thereof | 湖南中医药大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-119661342-A | Curcumin derivative and preparation method thereof, nano-composite and preparation method and application thereof | 湖南中医药大学 | 2025-03-21 | — | — | CN | disclosed |
| WO-2022090877-A1 | METAL COMPLEXES OF DIARYLHEPTANOIDS AND ITS DERIVATIVES | ARJUNA NATURAL PRIVATE LIMITED (IN) | 2022-05-05 | — | — | WO | disclosed |
| US-9074238-B2 | Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
| EP-1933625-B1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHYDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | LAILA NUTRACEUTICALS (IN) | 2014-07-09 | — | — | EP | disclosed |
| US-8680143-B2 | Orally active curcuminoid compounds | LAILA PHARMACEUTICALS PVT. LTD. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8568802-B2 | Process for producing enriched fractions of tetrahydroxycurcumin and tetrahydrotetrahydroxy-curcumin from the extracts of Curcuma longa | LAILA IMPEX (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110112190-A1 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | LAILA PHARMACEUTICALS PVT. LTD. (IN) | 2011-05-12 | — | — | US | disclosed |
| EP-1933625-A1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHYDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | Gokaraju, Ganga, Raju (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007043058-A1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHYDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | GOKARAJU GANGA RAJU (IN) | 2007-04-19 | — | — | WO | disclosed |
| EP-1299406-B1 | CURCUMIN DERIVATIVES WITH IMPROVED WATER SOLUBILITY COMPARED TO CURCUMIN AND MEDICAMENTS CONTAINING THE SAME | DEUTSCHES KREBSFORSCH (DE) | 2005-10-26 | — | — | EP | disclosed |
| US-20030153512-A1 | Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2003-08-14 | — | — | US | disclosed |
| EP-1299406-A1 | CURCUMIN DERIVATIVES WITH IMPROVED WATER SOLUBILITY COMPARED TO CURCUMIN AND MEDICAMENTS CONTAINING THE SAME | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002002582-A1 | CURCUMIN DERIVATIVES WITH IMPROVED WATER SOLUBILITY COMPARED TO CURCUMIN AND MEDICAMENTS CONTAINING THE SAME | DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2002-01-10 | — | — | WO | disclosed |
| WO-1994004139-A9 | TREATMENT OF HUMAN VIRAL INFECTIONS | — | 1994-04-28 | — | — | WO | disclosed |
| WO-1994004139-A1 | TREATMENT OF HUMAN VIRAL INFECTIONS | DANA FARBER CANCER INSTITUTE (US) | 1994-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153512-A1 | Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same | CD44, TNF, CD14 | IAPP 1882/4885APP 1353/4885BACE1 921/4885 |
| US-20120039828-A1 | Photoprotector and/or photoimmunoprotector compositions of the skin and their uses | ME1, ME2, SI | IAPP 4480/4885APP 3879/4885BACE1 2593/4885 |
| US-20110112190-A1 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | ALOX12, ALOX15, ALOX15B | IAPP 2851/4885APP 2187/4885BACE1 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.