Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.56 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681424 | 0.87 | TBXA2R (0.59) | MAPTTBXA2RDRD2AGTR1AGTR2 | |
| SCHEMBL9699122 | 0.86 | TP53 (0.58) | MAPTTBXA2RDRD2AGTR1AGTR2 | |
| SCHEMBL9699166 | 0.85 | TBXA2R (0.72) | TBXA2RAGTR1AGTR2PPARG | |
| SCHEMBL9681247 | 0.84 | ENPP2 (0.46) | MAPTTBXA2RDRD2LMNAPDE4D | |
| SCHEMBL9699244 | 0.84 | ENPP2 (0.64) | MAPTTBXA2RLMNATP53MEN1 | |
| SCHEMBL9682881 | 0.79 | TBXA2R (0.69) | TBXA2RAGTR1AGTR2PPARG | |
| SCHEMBL13186949 | 0.76 | HIF1A (0.67) | MAPTTBXA2RDRD2HIF1ATDP1 | |
| Clemizole SCHEMBL19976083 | 0.76 | HIF1A (0.80) | MAPTHIF1ATDP1NR1I2ABCB11 | |
| Hydrochloric Acid SCHEMBL29205453 | 0.75 | HIF1A (0.64) | MAPTTBXA2RDRD2SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL30282000 | 0.75 | HIF1A (0.64) | MAPTTBXA2RDRD2SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |