Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682037 | 0.88 | RXFP1 (0.44) | ENPP2MAPTLMNAMEN1KMT2A | |
| SCHEMBL9683183 | 0.84 | MAPT (0.62) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL9699244 | 0.84 | ENPP2 (0.64) | ENPP2MAPTLMNAMEN1KMT2A | |
| SCHEMBL9699166 | 0.77 | TBXA2R (0.72) | TBXA2R | |
| SCHEMBL9683089 | 0.74 | TBXA2R (0.73) | TBXA2R | |
| SCHEMBL9681424 | 0.72 | TBXA2R (0.59) | MAPTTBXA2RDRD2TP53POLB | |
| SCHEMBL9700220 | 0.72 | MAPT (0.56) | ENPP2MAPTLMNAMEN1KMT2A | |
| SCHEMBL9681986 | 0.72 | NPSR1 (0.50) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL20715514 | 0.72 | NPSR1 (0.45) | MAPTLMNAMEN1KMT2ANPSR1 | |
| SCHEMBL9699122 | 0.72 | TP53 (0.58) | MAPTLMNAMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |