Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726553 | 1.00 | NPC1 (0.64) | NPC1MAPTMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL9324495 | 0.98 | MAPT (0.67) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL7590256 | 0.90 | ALDH1A1 (0.56) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL7590251 | 0.90 | ALDH1A1 (0.56) | NPC1MAPTMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL10353456 | 0.88 | EGFR (0.58) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL11439856 | 0.85 | EGFR (0.57) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL9850638 | 0.83 | CHRM2 (0.51) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL10589581 | 0.82 | HTT (0.83) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL9850647 | 0.81 | EGFR (0.50) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL9859087 | 0.81 | EGFR (0.50) | NPC1MAPTMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132457-A | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| US-5132457-A | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| US-5132457-A | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1992-07-21 | — | — | US | disclosed |