Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 8/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.30 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224451 | 0.94 | PPARG (0.35) | PPARGPTGESALOX5CNR1CNR2 | |
| SCHEMBL15008371 | 0.87 | PSEN1 (0.34) | ALOX5CNR1CNR2MAPTHMGCR | |
| Bumetrizole SCHEMBL8164248 | 0.84 | NPC1 (0.40) | NPC1RAB9APOLB | |
| Bumetrizole SCHEMBL11754863 | 0.84 | FFAR4 (0.40) | NPC1RAB9A | |
| SCHEMBL547105 | 0.84 | PTGES (0.41) | NPC1RAB9APPARGPTGESALOX5 | |
| SCHEMBL208254 | 0.84 | MMP2 (0.33) | PPARGPTGESALOX5MMP2 | |
| SCHEMBL208252 | 0.83 | PPARG (0.31) | PPARGCNR1CNR2PPARAPPARD | |
| Bumetrizole SCHEMBL8379731 | 0.81 | NPC1 (0.42) | NPC1RAB9ACNR1CNR2POLB | |
| Bumetrizole SCHEMBL11761050 | 0.81 | NPC1 (0.35) | NPC1RAB9APOLBHMGCR | |
| Bumetrizole SCHEMBL3834201 | 0.81 | NPC1 (0.45) | NPC1RAB9APOLBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124456-A | HINDERED AMINE-SUBSTITUTED DIHYDROPYRIDINES AND HEAT/LIGHT STABILIZATION OF POLYMER SUBSTRATES THEREWITH | RHONE-POULENC CHIMIE (FR) | 1992-06-23 | — | — | US | disclosed |