Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351441 | 0.83 | REN (0.57) | RENMETAP2METAP1 | |
| SCHEMBL7345478 | 0.81 | REN (0.61) | RENMETAP2METAP1 | |
| SCHEMBL7315975 | 0.81 | REN (0.61) | RENMETAP2METAP1 | |
| SCHEMBL8826686 | 0.80 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9575386 | 0.78 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9858518 | 0.78 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL9685661 | 0.78 | REN (0.56) | RENMETAP2METAP1 | |
| SCHEMBL14415380 | 0.78 | REN (0.60) | RENMETAP2METAP1 | |
| SCHEMBL14420289 | 0.78 | REN (0.60) | RENMETAP2METAP1 | |
| SCHEMBL7445593 | 0.78 | REN (0.40) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091425-A | Inhibitors of the catalytic action of renin | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-25 | — | — | US | disclosed |