Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684562 | 0.71 | POLB (0.43) | POLBLRRK2ALDH1A1HPGDKDM4E | |
| SCHEMBL25225077 | 0.64 | KDM4E (0.41) | ALDH1A1KDM4ENPSR1ADORA1ERBB2 | |
| SCHEMBL9684081 | 0.63 | POLB (0.48) | POLBALDH1A1HPGDKDM4EMAOA | |
| SCHEMBL9040621 | 0.62 | MAOA (0.47) | POLBLRRK2ALDH1A1KDM4EMAOA | |
| SCHEMBL9042248 | 0.61 | LRRK2 (0.43) | LRRK2ALDH1A1HPGDKDM4EMAOA | |
| SCHEMBL10919832 | 0.60 | HTR2A (0.71) | KMT2AMEN1 | |
| SCHEMBL18932886 | 0.60 | HTR2A (0.71) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL29019631 | 0.60 | MCL1 (0.41) | LRRK2ALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL1905542 | 0.60 | ADORA1 (0.46) | POLBLRRK2ALDH1A1HPGDKDM4E | |
| SCHEMBL19676926 | 0.60 | CYP1A2 (0.50) | KMT2AMEN1CYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |