Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.38 |
| ▸ | PRNP | P04156 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683476 | 0.92 | KDM1A (0.36) | CYP2D6HTR2AHRH1CYP1A2SLC22A1 | |
| SCHEMBL9684167 | 0.81 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL9683338 | 0.81 | POLB (0.34) | CYP2D6CYP1A2TP53TSHRCYP2C19 | |
| SCHEMBL9684632 | 0.81 | SLC6A2 (0.36) | CYP2D6HTR2AHRH1CYP1A2SLC22A1 | |
| SCHEMBL9683517 | 0.78 | HTT (0.30) | — | |
| SCHEMBL9683453 | 0.78 | OPRM1 (0.35) | SLC6A2SLC6A4OPRM1SLC6A3 | |
| SCHEMBL9683465 | 0.77 | CARM1 (0.33) | CYP2D6HTR2AHRH1CYP1A2CHRM2 | |
| SCHEMBL9682581 | 0.72 | HTT (0.35) | SLC6A2SLC6A4KDM4ESLC6A3ACHE | |
| SCHEMBL9684243 | 0.72 | CHRM2 (0.37) | CHRM2CHRM4CHRM5TP53SIGMAR1 | |
| SCHEMBL9684281 | 0.71 | OPRM1 (0.37) | OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475187-A1 | Naphthothiophenimines for treating neuronal disorders caused by ischemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-03-18 | — | — | EP | disclosed |