Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10636768 | 0.79 | ACACB (0.64) | ACACB | |
| SCHEMBL10636765 | 0.79 | ACACB (0.64) | ACACB | |
| SCHEMBL9811917 | 0.78 | SIGMAR1 (0.54) | SIGMAR1SLC2A1PPARGPPARDPPARA | |
| SCHEMBL9782119 | 0.77 | ACACB (0.72) | ACACB | |
| SCHEMBL10636528 | 0.77 | ACACB (0.50) | ACACBSIGMAR1SLC2A1PPARGPPARD | |
| SCHEMBL10772481 | 0.76 | SIGMAR1 (0.65) | ACACBSIGMAR1SLC2A1PPARGPPARD | |
| SCHEMBL9492053 | 0.74 | ADRB3 (0.50) | ACACBSIGMAR1SLC2A1POLBMEN1 | |
| SCHEMBL8881007 | 0.74 | ACACB (0.58) | ACACBSIGMAR1SLC2A1POLBALDH1A1 | |
| SCHEMBL9787803 | 0.74 | ACACB (0.63) | ACACBALDH1A1MEN1KMT2ATAAR1 | |
| SCHEMBL215246 | 0.73 | KCNA3 (0.58) | ALDH1A1MEN1KMT2ATAAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | claimed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | claimed |
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |