Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803282 | 0.88 | MCOLN3 (0.37) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL70441 | 0.86 | CYP2D6 (0.46) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL17621817 | 0.83 | CYP2D6 (0.38) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL24238344 | 0.81 | OPRM1 (0.42) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL24238281 | 0.81 | OPRM1 (0.42) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL5514265 | 0.80 | CYP2D6 (0.41) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL24238345 | 0.79 | CYP2D6 (0.40) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL2264060 | 0.78 | CYP2D6 (0.45) | CYP2D6CHRM2CHRM1KMT2AMEN1 | |
| SCHEMBL9682608 | 0.78 | CYP2D6 (0.45) | CYP2D6MC4RCHRM2CHRM1LMNA | |
| SCHEMBL2265275 | 0.78 | CYP2D6 (0.45) | CYP2D6CHRM2CHRM1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| US-5130309-A | Cardiovascular disorders | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-07-14 | — | — | US | disclosed |