Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686738 | 0.86 | FNTA (0.44) | PTPN11KDM4EMAPK1MEN1KMT2A | |
| SCHEMBL9686692 | 0.71 | ABCC1 (0.41) | KDM4EMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL16651754 | 0.70 | HDAC1 (0.56) | PTPN11MEN1KMT2ANPSR1HDAC1 | |
| SCHEMBL15344316 | 0.70 | HDAC1 (0.55) | PTPN11MEN1KMT2ANPSR1HDAC1 | |
| SCHEMBL20425032 | 0.70 | MEN1 (0.53) | PTPN11MEN1KMT2ANPSR1HDAC1 | |
| SCHEMBL15344305 | 0.69 | HDAC1 (0.54) | PTPN11MEN1KMT2ANPSR1HDAC1 | |
| SCHEMBL16651298 | 0.68 | HDAC1 (0.53) | PTPN11MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL16652543 | 0.68 | MEN1 (0.48) | PTPN11MEN1KMT2AHPGDNPSR1 | |
| SCHEMBL4498884 | 0.68 | ACHE (0.52) | PTPN11KDM4EMAPK1MEN1KMT2A | |
| SCHEMBL31286939 | 0.68 | GPR119 (0.52) | KDM4EMEN1KMT2ANPSR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |