Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CASP1 | P29466 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686738 | 0.86 | FNTA (0.44) | ABCC1ALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL9686871 | 0.79 | CYP1A2 (0.43) | ALDH1A1HSD17B10CASP1USP2CYP1A2 | |
| SCHEMBL9686660 | 0.74 | HTT (0.48) | ALDH1A1HSD17B10CASP1USP2TSHR | |
| SCHEMBL9684377 | 0.71 | PTPN11 (0.42) | ALDH1A1HSD17B10CASP1HPGDKDM4E | |
| SCHEMBL9686146 | 0.70 | HTT (0.46) | ALDH1A1HSD17B10CASP1USP2TSHR | |
| SCHEMBL9685325 | 0.66 | CYP1A2 (0.46) | ALDH1A1HSD17B10CASP1USP2CYP1A2 | |
| SCHEMBL9684556 | 0.65 | LMNA (0.51) | ALDH1A1HSD17B10CASP1TSHRHPGD | |
| SCHEMBL9686858 | 0.63 | HTR3A (0.55) | ALDH1A1HSD17B10CASP1USP2CYP1A2 | |
| SCHEMBL9686741 | 0.62 | CYP1A2 (0.41) | ALDH1A1HSD17B10CASP1USP2CYP1A2 | |
| SCHEMBL3521025 | 0.60 | MAOB (0.49) | ALDH1A1HSD17B10CASP1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |