Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686157 | 0.90 | NPSR1 (0.55) | TRPA1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9685139 | 0.89 | TRPA1 (0.56) | TRPA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9686152 | 0.88 | TRPA1 (0.54) | TRPA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9686160 | 0.86 | TRPA1 (0.54) | TRPA1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9686751 | 0.85 | TRPA1 (0.61) | TRPA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9685239 | 0.85 | TRPA1 (0.60) | TRPA1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9686804 | 0.84 | TRPA1 (0.52) | TRPA1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9685113 | 0.83 | TRPA1 (0.58) | TRPA1LMNAHTTPTPN11 | |
| SCHEMBL3957492 | 0.82 | HDAC6 (0.57) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9686641 | 0.81 | TRPA1 (0.57) | TRPA1LMNAHTTPTPN11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61043173-A | — | — | None | — | — | JP | disclosed |
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |
| JP-S6143173-A | NOVEL PYRIMIDINE DRIVATIVE AND PREPARATION THEREOF | MITSUI PETROCHEM IND LTD | 1986-03-01 | — | — | JP | disclosed |