Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP5 | P51878 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP4 | P49662 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685139 | 0.95 | TRPA1 (0.56) | TRPA1LMNAHTTSMN1; SMN2POLB | |
| SCHEMBL9686160 | 0.86 | TRPA1 (0.54) | TRPA1LMNAHTTSMN1; SMN2POLB | |
| SCHEMBL9684387 | 0.84 | TRPA1 (0.55) | TRPA1LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9686157 | 0.83 | NPSR1 (0.55) | TRPA1LMNAHTTSMN1; SMN2POLB | |
| SCHEMBL9685239 | 0.83 | TRPA1 (0.60) | TRPA1LMNAHTTSMN1; SMN2POLB | |
| SCHEMBL9685113 | 0.81 | TRPA1 (0.58) | TRPA1LMNAHTT | |
| SCHEMBL8809831 | 0.81 | TRPA1 (0.52) | TRPA1LMNAHTTALDH1A1CASP1 | |
| SCHEMBL32671622 | 0.80 | POLB (0.75) | LMNASMN1; SMN2POLBALDH1A1CASP1 | |
| SCHEMBL9686641 | 0.79 | TRPA1 (0.57) | TRPA1LMNAHTT | |
| SCHEMBL9685068 | 0.79 | TRPA1 (0.64) | TRPA1LMNAHTTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |