Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684857 | 0.88 | AKR1B1 (0.79) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9872084 | 0.88 | AKR1B1 (0.79) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL9870040 | 0.85 | AKR1B1 (0.73) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL8320456 | 0.80 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL9535759 | 0.75 | AKR1B1 (0.60) | AKR1B1AKR1B10AKR1A1CHRM5MEN1 | |
| SCHEMBL9034547 | 0.72 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1CHRM5TBXA2R | |
| SCHEMBL9036585 | 0.72 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1CHRM5TBXA2R | |
| SCHEMBL9685018 | 0.71 | AKR1B1 (0.55) | AKR1B1MEN1KMT2A | |
| SCHEMBL10431907 | 0.71 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1MEN1KMT2A | |
| SCHEMBL9383937 | 0.71 | AKR1B1 (0.54) | AKR1B1CHRM5MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | claimed |
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |