Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.79 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870040 | 0.89 | AKR1B1 (0.73) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL9685013 | 0.88 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL8320456 | 0.84 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1CHRM5GRM5 | |
| SCHEMBL9383937 | 0.77 | AKR1B1 (0.54) | AKR1B1CHRM5MAPT | |
| SCHEMBL9684857 | 0.77 | AKR1B1 (0.79) | AKR1B1CHRM5 | |
| SCHEMBL8323716 | 0.75 | AKR1B1 (0.54) | AKR1B1CHRM5GRM5MAPT | |
| SCHEMBL9385583 | 0.75 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1CHRM5MAPT | |
| SCHEMBL10431907 | 0.72 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL9385856 | 0.71 | AKR1B1 (0.49) | AKR1B1AKR1A1CHRM5MAPT | |
| SCHEMBL8322894 | 0.71 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |