Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.79 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685013 | 0.88 | AKR1B1 (1.00) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9535759 | 0.85 | AKR1B1 (0.60) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL8323716 | 0.79 | AKR1B1 (0.54) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9872084 | 0.77 | AKR1B1 (0.79) | AKR1B1CHRM5 | |
| SCHEMBL9870040 | 0.74 | AKR1B1 (0.73) | AKR1B1CHRM5 | |
| SCHEMBL9383937 | 0.73 | AKR1B1 (0.54) | AKR1B1CHRM5MEN1KMT2AHSD17B10 | |
| SCHEMBL9871059 | 0.73 | APAF1 (0.50) | AKR1B1MEN1CYP1A2KMT2AHSD17B10 | |
| SCHEMBL9036577 | 0.72 | AKR1B1 (0.50) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9036089 | 0.71 | AKR1B1 (0.52) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL8320456 | 0.70 | AKR1B1 (0.66) | AKR1B1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |