Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323716 | 0.87 | AKR1B1 (0.54) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9684857 | 0.85 | AKR1B1 (0.79) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL8320456 | 0.76 | AKR1B1 (0.66) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL9383524 | 0.76 | AKR1B1 (0.45) | AKR1B1CHRM5MEN1KMT2A | |
| SCHEMBL11798036 | 0.75 | PPIA (0.41) | AKR1B1KMT2A | |
| SCHEMBL9685013 | 0.75 | AKR1B1 (1.00) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9385856 | 0.74 | AKR1B1 (0.49) | AKR1B1CHRM5AKR1A1 | |
| SCHEMBL9385583 | 0.74 | AKR1B1 (0.54) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL8906538 | 0.72 | AKR1B1 (0.49) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL11791998 | 0.71 | KMT2A (0.53) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555327-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992006974-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |