Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685098 | 0.75 | DHODH (0.38) | DHODHSTAT3ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10726039 | 0.75 | DHODH (0.38) | DHODHSTAT3ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL11280289 | 0.73 | GAA (0.41) | STAT3ALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL10731053 | 0.73 | HPGD (0.41) | DHODHSTAT3ALDH1A1LMNARECQL | |
| SCHEMBL10731065 | 0.73 | HPGD (0.41) | DHODHSTAT3ALDH1A1LMNARECQL | |
| SCHEMBL13433912 | 0.71 | KMT2A (0.40) | DHODHSTAT3PKMALDH1A1LMNA | |
| SCHEMBL7305249 | 0.70 | ALDH1A1 (0.42) | PKMALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL14779262 | 0.70 | GAA (0.46) | DHODHALDH1A1SMN1; SMN2KMT2AGAA | |
| SCHEMBL4056460 | 0.69 | HPGD (0.44) | DHODHSTAT3PKMALDH1A1LMNA | |
| SCHEMBL6686680 | 0.69 | LMNA (0.40) | DHODHSTAT3PKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4871755-A | Method for treating diabetes obesity and conditions characterized by increased protein breakdown with novel oxazolidines | HOFFMANN-LA ROCHE INC. (US) | 1989-10-03 | — | — | US | disclosed |
| US-4743604-A | ANTIBESITY, ANTIDIABETIC, FEEDS | HOFFMANN-LA ROCHE INC. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |