Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686157 | 0.89 | NPSR1 (0.55) | PTPN11RAB9ASMN1; SMN2ALDH1A1PRMT1 | |
| SCHEMBL9298122 | 0.88 | PRMT1 (0.51) | PTPN11RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9685436 | 0.88 | PRMT1 (0.51) | PTPN11RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9684629 | 0.88 | PRMT1 (0.51) | PTPN11RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8812552 | 0.87 | ALOX15 (0.51) | PTPN11SMN1; SMN2ALDH1A1TSHRPRMT1 | |
| SCHEMBL9685091 | 0.85 | TRPA1 (0.59) | PTPN11RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9686678 | 0.84 | TRPA1 (0.56) | PTPN11RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL31254423 | 0.83 | PTPN11 (0.58) | PTPN11NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11870333 | 0.82 | TRPA1 (0.46) | PTPN11SMN1; SMN2ALDH1A1TSHRPRMT1 | |
| SCHEMBL1618023 | 0.82 | PRMT1 (0.61) | ALDH1A1TSHRPRMT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |