Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685378 | 1.00 | MEN1 (0.67) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL11017442 | 0.87 | KMT2A (0.64) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL9684249 | 0.85 | MEN1 (0.61) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL9684254 | 0.85 | MEN1 (0.61) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL9685281 | 0.84 | MEN1 (0.63) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL9685272 | 0.84 | MEN1 (0.63) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL9684139 | 0.79 | MEN1 (0.57) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL11373385 | 0.79 | ADRB2 (0.72) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| Oxalic Acid SCHEMBL9683314 | 0.79 | MEN1 (0.76) | MEN1KMT2AALDH1A1ADRB3ADRB2 | |
| SCHEMBL18461272 | 0.76 | KMT2A (0.72) | MEN1KMT2AALDH1A1ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |