Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 7/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685147 | 0.86 | ACKR3 (0.46) | CYP2D6CYP1A2MEN1KMT2ANPC1 | |
| SCHEMBL9685156 | 0.86 | ACKR3 (0.46) | CYP2D6CYP1A2MEN1KMT2ANPC1 | |
| SCHEMBL9684877 | 0.85 | ADRB1 (0.51) | ADRB1ADRB3ADRB2CYP3A4CYP2D6 | |
| SCHEMBL9684869 | 0.85 | ADRB1 (0.51) | ADRB1ADRB3ADRB2CYP3A4CYP2D6 | |
| SCHEMBL9685296 | 0.85 | ATM (0.45) | ADRB1ADRB3ADRB2ATMCYP1A2 | |
| SCHEMBL9685304 | 0.85 | ATM (0.45) | ADRB1ADRB3ADRB2ATMCYP1A2 | |
| SCHEMBL9685473 | 0.84 | ADRB1 (0.50) | ADRB1ADRB3ADRB2ATMCYP1A2 | |
| SCHEMBL9685479 | 0.84 | ADRB1 (0.50) | ADRB1ADRB3ADRB2ATMCYP1A2 | |
| SCHEMBL9684239 | 0.78 | MEN1 (0.48) | ADRB1ADRB3ADRB2ATMCYP1A2 | |
| SCHEMBL9684236 | 0.78 | MEN1 (0.48) | ADRB1ADRB3ADRB2ATMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |