Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534423 | 0.72 | MAPT (0.39) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| Hydrochloric Acid SCHEMBL11047993 | 0.71 | MAPT (0.38) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL8348805 | 0.68 | DHFR (0.46) | — | |
| SCHEMBL8725693 | 0.64 | ALDH1A1 (0.64) | LMNAMAPTHTTKMT2AHIF1A | |
| SCHEMBL10369590 | 0.63 | CYP3A4 (0.37) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL29463764 | 0.63 | CYP3A4 (0.37) | MEN1LMNAHSP90AA1HSP90AB1MAPT | |
| SCHEMBL11211809 | 0.61 | MEN1 (0.37) | MEN1LMNAMAPTBLMKMT2A | |
| SCHEMBL29429655 | 0.60 | ALDH1A1 (0.45) | MEN1MAPTKMT2A | |
| SCHEMBL10348834 | 0.59 | MAPT (0.52) | MEN1LMNAMAPTHTTBLM | |
| SCHEMBL30530989 | 0.59 | EP300 (0.44) | MEN1LMNAHSP90AA1HSP90AB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |