Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22323003 | 0.86 | ALDH1A1 (0.40) | POLBHPGDSMN1; SMN2TLR4ALDH1A1 | |
| SCHEMBL22216375 | 0.81 | POLB (0.44) | POLBHPGDSMN1; SMN2TLR4ALDH1A1 | |
| SCHEMBL22216157 | 0.81 | POLB (0.41) | POLBHPGDSMN1; SMN2TLR4ALDH1A1 | |
| SCHEMBL3286134 | 0.80 | POLB (0.43) | POLBHPGDSMN1; SMN2TLR4ALDH1A1 | |
| SCHEMBL9685183 | 0.75 | ALDH1A1 (0.42) | POLBHPGDTLR4ALDH1A1MAPT | |
| SCHEMBL22216178 | 0.75 | MAPT (0.52) | POLBHPGDTLR4ALDH1A1MAPT | |
| SCHEMBL30200073 | 0.74 | TLR4 (0.38) | POLBHPGDSMN1; SMN2TLR4ALDH1A1 | |
| SCHEMBL10366484 | 0.73 | ALDH1A1 (0.49) | POLBHPGDTLR4ALDH1A1MAPT | |
| SCHEMBL23000018 | 0.72 | TP53 (0.47) | HPGDSMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL9686831 | 0.72 | ALDH1A1 (0.34) | POLBHPGDTLR4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245053-B1 | HETEROCYCLIC FUSED TRICYCLIC COMPOUNDS | ICI AMERICAS INC. (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0245053-A1 | Heterocyclic fused tricyclic compounds | ICI AMERICAS INC. (US) | 1987-11-11 | — | — | EP | disclosed |