Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685183 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPTTLR4POLBLMNA | |
| SCHEMBL10366484 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTTLR4POLBKMT2A | |
| SCHEMBL3367604 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTTLR4KMT2AKDM4E | |
| SCHEMBL10367891 | 0.72 | MAPT (0.38) | ALDH1A1MAPTPOLBLMNAKMT2A | |
| SCHEMBL9685715 | 0.72 | POLB (0.39) | ALDH1A1MAPTTLR4POLBKMT2A | |
| SCHEMBL22216178 | 0.72 | MAPT (0.52) | ALDH1A1MAPTTLR4POLBKMT2A | |
| SCHEMBL22715440 | 0.71 | ALDH1A1 (0.61) | ALDH1A1MAPTTLR4ELANECTSG | |
| SCHEMBL9042858 | 0.70 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNAKMT2AKDM4E | |
| SCHEMBL11732751 | 0.69 | ALDH1A1 (0.40) | ALDH1A1MAPTTLR4ELANECTSG | |
| SCHEMBL22216464 | 0.69 | MAPT (0.40) | ALDH1A1MAPTTLR4LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245053-B1 | HETEROCYCLIC FUSED TRICYCLIC COMPOUNDS | ICI AMERICAS INC. (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0178759-B1 | ALKYNYL DERIVATIVESOF PYRAZOLO-(3,4-B)-PYRIDINE LACTAMS | ICI AMERICAS INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0245053-A1 | Heterocyclic fused tricyclic compounds | ICI AMERICAS INC. (US) | 1987-11-11 | — | — | EP | disclosed |
| US-4705793-A | Pyrazolo[3,4-b]pyrrolo[3,4-e]pyridine-5(1H)-one and 1-H-pyrazolo[3,4-b][1,6]naphthyridine-5(6H)-one derivations, useful as anti-anxiety agents | ICI AMERICAS INC. (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0178759-A1 | Alkynyl derivativesof pyrazolo-(3,4-b)-pyridine lactams | ICI AMERICAS INC. (US) | 1986-04-23 | — | — | EP | disclosed |