Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514024 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDNPSR1MAPK1ALOX15 | |
| SCHEMBL1310441 | 0.73 | HSP90AA1 (0.62) | NAMPTALDH1A1HPGDGAAMAPK1 | |
| 1,2-Dimethoxybenzene SCHEMBL12979050 | 0.70 | CA1 (0.48) | ALDH1A1MAPK1CLK1DYRK1ADYRK1B | |
| SCHEMBL10075563 | 0.69 | ALDH1A1 (1.00) | ALDH1A1HPGDNPSR1MAPK1SMN1; SMN2 | |
| SCHEMBL1310766 | 0.68 | GAA (1.00) | NAMPTALDH1A1HPGDNPSR1GAA | |
| SCHEMBL227125 | 0.67 | TSHR (0.61) | ALDH1A1HPGDNPSR1GAALMNA | |
| SCHEMBL30612357 | 0.67 | TSHR (0.61) | ALDH1A1HPGDNPSR1GAALMNA | |
| SCHEMBL14972764 | 0.66 | KMT2A (0.66) | NAMPTALDH1A1GAAMAPK1CLK1 | |
| SCHEMBL14972763 | 0.66 | KMT2A (0.66) | NAMPTALDH1A1GAAMAPK1CLK1 | |
| SCHEMBL21067997 | 0.65 | HSP90AA1 (1.00) | NAMPTALDH1A1GAAMAPK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | disclosed |
| US-5051508-A | Antisecretory agents and enzyme inhibitors as antiulcer agents | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1991-09-24 | — | — | US | disclosed |
| EP-0307078-A1 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1989-03-15 | — | — | EP | disclosed |