Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071424 | 0.85 | TP53 (0.60) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL42480 | 0.83 | TP53 (0.47) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL28203775 | 0.82 | OGFRL1 (0.46) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL11791438 | 0.81 | OPRM1 (0.45) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL9685823 | 0.81 | RPS6KB1 (0.47) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL7587030 | 0.81 | CCR5 (0.54) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL6248701 | 0.81 | OPRM1 (0.59) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| Hydrochloric Acid SCHEMBL11213404 | 0.80 | RPS6KB1 (0.46) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| Hydrochloric Acid SCHEMBL4379304 | 0.80 | CCR5 (0.53) | TP53OPRM1OPRD1OPRK1OGFRL1 | |
| Hydrochloric Acid SCHEMBL6165995 | 0.80 | OPRM1 (0.50) | TP53OPRM1OPRD1OPRK1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008264-A | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-16 | — | — | US | disclosed |