Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.66 |
| ▸ | ACHE | P22303 | 5/20 | 0.61 |
| ▸ | BCHE | P06276 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | BACE1 | P56817 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647170 | 0.86 | PTGS2 (0.66) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL29559360 | 0.83 | PTGS2 (0.71) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL11795154 | 0.81 | PTGS2 (0.63) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL11795164 | 0.81 | PTGS2 (0.63) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL31361989 | 0.80 | MAPT (0.72) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL366120 | 0.79 | TSHR (0.60) | PTGS2ACHEMAPTNPSR1ALDH1A1 | |
| SCHEMBL9507521 | 0.79 | MAPT (0.61) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL10430142 | 0.79 | PTGS2 (0.64) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL1650914 | 0.79 | PTGS2 (0.82) | PTGS2ACHEBCHEMAPTBACE1 | |
| SCHEMBL1650911 | 0.79 | PTGS2 (0.82) | PTGS2ACHEBCHEMAPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489547-A1 | A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof | ZENECA LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |