Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PPIA | P62937 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | PNLIP | P16233 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979300 | 0.84 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL6300571 | 0.84 | KMT2A (0.83) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL11359908 | 0.84 | NPC1 (0.66) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL11238363 | 0.82 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2ATDP1 | |
| Chlorbenzuron SCHEMBL5177776 | 0.81 | GCGR (0.68) | NPC1RAB9AMEN1KMT2ATDP1 | |
| Diflubenzuron SCHEMBL42416 | 0.80 | RAB9A (0.59) | NPC1RAB9AMEN1KMT2APPIA | |
| Diflubenzuron SCHEMBL18837607 | 0.80 | RAB9A (0.59) | NPC1RAB9AMEN1KMT2APPIA | |
| SCHEMBL8840336 | 0.79 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL11141981 | 0.79 | MEN1 (0.59) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8840355 | 0.79 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166180-A | Administering diphenyl substituted (thio)carbonyl(thio)urea derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-11-24 | — | — | US | claimed |
| US-5166180-A | Administering diphenyl substituted (thio)carbonyl(thio)urea derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-11-24 | — | — | US | disclosed |
| EP-0324521-A2 | Method of treating haematologic diseases and pharmaceutical compositions to be used therefor | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1989-07-19 | — | — | EP | disclosed |