SCHEMBL9686594

SCHEMBL9686594

Cn1[nH]c2nc(N3CCN(Cc4ccccc4)CC3)ncc2c1=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 5/20 0.52
LMNA P02545 3/20 0.52
GAA P10253 2/20 0.46
TRPA1 O75762 1/20 0.46
HTR2C P28335 2/20 0.45
HTR2A P28223 1/20 0.45
ALDH1A1 P00352 4/20 0.45
TSHR P16473 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
HPGD P15428 2/20 0.45
HSD17B10 Q99714 1/20 0.45
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
CASP1 P29466 1/20 0.44
CASP5 P51878 1/20 0.44
NPSR1 Q6W5P4 2/20 0.43
ACHE P22303 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 2/20 0.43
HTR7 P34969 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10824470 0.77 LMNA (0.54) HTTLMNAGAAALDH1A1TSHR
SCHEMBL9298962 0.76 HTT (0.64) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL9684556 0.75 LMNA (0.51) HTTLMNAGAATRPA1HTR2A
SCHEMBL9686660 0.72 HTT (0.48) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL8898023 0.72 HTT (0.64) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL8808269 0.72 HTT (0.53) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL8810642 0.71 HTT (0.52) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL8808175 0.70 HTT (0.65) HTTLMNAGAAALDH1A1TSHR
SCHEMBL8809105 0.70 HTT (0.51) HTTLMNAGAATRPA1ALDH1A1
SCHEMBL10521164 0.70 HTT (0.51) HTTLMNAGAATRPA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61243083-A None JP disclosed
EP-0188094-B1 QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1992-03-18 EP disclosed
US-4734418-A Quinazoline compounds and antihypertensives MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-03-29 US disclosed
JP-S61243083-A 6-PIPERAZINO-3-OXO-2,3-DIHYDRO-1H-PYRAZOLO(3,4-D)-PYRIMIDINE COMPOUND MITSUI PETROCHEM IND LTD 1986-10-29 JP disclosed
EP-0188094-A2 Quinazoline derivatives and antihypertensive preparations containing same as effective components MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1986-07-23 EP disclosed