Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10824274 | 0.89 | NPC1 (0.48) | LMNAHTTNPC1RAB9AGRM2 | |
| SCHEMBL9686858 | 0.85 | HTR3A (0.55) | LMNAKDM4EMAPK1HTR1ADRD2 | |
| SCHEMBL9686660 | 0.82 | HTT (0.48) | LMNAHTTNPC1RAB9AKDM4E | |
| SCHEMBL9685229 | 0.81 | USP19 (0.51) | LMNAMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9686146 | 0.80 | HTT (0.46) | LMNAHTTNPC1RAB9AMAPT | |
| SCHEMBL9686777 | 0.79 | GRM2 (0.48) | LMNAHTTRAB9AGRM2KDM4E | |
| SCHEMBL13404501 | 0.77 | HTR3E (0.54) | LMNANPC1RAB9AKDM4EMAPT | |
| SCHEMBL9686198 | 0.77 | TSHR (0.40) | TSHRMEN1KMT2A | |
| SCHEMBL10824470 | 0.76 | LMNA (0.54) | LMNAHTTNPC1RAB9AGRM2 | |
| SCHEMBL9685405 | 0.76 | PRMT1 (0.46) | LMNAHTTKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61057581-A | — | — | None | — | — | JP | disclosed |
| JP-61053284-A | — | — | None | — | — | JP | disclosed |
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |
| JP-S6157581-A | 1,4-DIHYDRO-2-PIPERAZINOPYRIDOPYRIMIDINE DERIVATIVE | MITSUI PETROCHEM IND LTD | 1986-03-24 | — | — | JP | disclosed |
| JP-S6153284-A | THIOXOPYRIDOPYRIMIDINE DERIVATIVE | MITSUI PETROCHEM IND LTD | 1986-03-17 | — | — | JP | disclosed |