SCHEMBL9686598

SCHEMBL9686598

CCN1C(=O)Cc2cnc(N3CCN(Cc4ccccc4)CC3)nc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 5/20 0.51
LMNA P02545 3/20 0.51
USP1 O94782 1/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
TSHR P16473 5/20 0.44
ALDH1A1 P00352 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
GAA P10253 2/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 1/20 0.44
HTR1A P08908 1/20 0.43
ACHE P22303 3/20 0.43
TRPA1 O75762 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CASP1 P29466 1/20 0.43
CASP5 P51878 1/20 0.43
HTR7 P34969 1/20 0.43
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8812154 0.87 ALDH1A1 (0.49) HTTLMNAUSP1NPC1RAB9A
SCHEMBL8808269 0.87 HTT (0.53) HTTLMNAUSP1NPC1RAB9A
SCHEMBL9686754 0.84 HTT (0.50) HTTLMNAUSP1NPC1RAB9A
SCHEMBL1847423 0.80 POLB (0.41) HTTLMNAUSP1TSHRALDH1A1
SCHEMBL9686746 0.78 ALDH1A1 (0.43) USP1TSHRALDH1A1SMN1; SMN2HPGD
SCHEMBL8810475 0.76 LMNA (0.53) HTTLMNANPC1RAB9ATSHR
SCHEMBL9686199 0.76 HTT (0.64) HTTLMNANPC1RAB9ATSHR
SCHEMBL8811313 0.76 HTR7 (0.44) HTTLMNANPC1TSHRALDH1A1
SCHEMBL8811787 0.75 LMNA (0.55) HTTLMNANPC1RAB9ATSHR
SCHEMBL1846364 0.74 LMNA (0.42) LMNATSHRALDH1A1HSD17B10HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0188094-B1 QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1992-03-18 EP disclosed
EP-0192783-B1 2-PIPERAZINOPYRIMIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1991-04-17 EP disclosed
US-4742165-A HERBICIDES MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-05-03 US disclosed
US-4734418-A Quinazoline compounds and antihypertensives MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-03-29 US disclosed
EP-0192783-A1 2-PIPERAZINOPYRIMIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1986-09-03 EP disclosed
EP-0188094-A2 Quinazoline derivatives and antihypertensive preparations containing same as effective components MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1986-07-23 EP disclosed