Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 4/20 | 0.42 |
| ▸ | ALPI | P09923 | 4/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | STS | P08842 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297750 | 0.95 | ALPL (0.43) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL1008446 | 0.89 | MMP2 (0.48) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL23449 | 0.83 | MMP2 (0.44) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL3863280 | 0.81 | KMT2A (0.53) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL6671842 | 0.80 | ALPL (0.39) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL27608810 | 0.80 | KMT2A (0.52) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL28444853 | 0.80 | KMT2A (0.52) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL27656352 | 0.80 | CA2 (0.50) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL11062482 | 0.79 | ALPL (0.45) | ALPLALPIMMP2MMP9MMP14 | |
| SCHEMBL29270364 | 0.79 | CA2 (0.48) | ALPLALPIMMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |