SCHEMBL9686697

SCHEMBL9686697

COc1ccnc(CSc2nc3cc(OC(F)(F)C(F)Cl)c(OC)cc3[nH]2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 3/20 0.56
NOS3 P29474 2/20 0.56
NOS1 P29475 2/20 0.56
CYP2E1 P05181 16/20 0.48
CYP2C8 P10632 16/20 0.48
CYP2D6 P10635 16/20 0.48
CYP2C9 P11712 16/20 0.48
CYP2B6 P20813 16/20 0.48
CYP2C19 P33261 16/20 0.48
CYP1A2 P05177 15/20 0.48
CYP3A4 P08684 15/20 0.48
ATP1A1 P05023 1/20 0.43
ATP1B1 P05026 1/20 0.43
ATP1A3 P13637 1/20 0.43
ATP1B2 P14415 1/20 0.43
ATP4A P20648 1/20 0.43
ATP1A2 P50993 1/20 0.43
ATP4B P51164 1/20 0.43
ATP1B3 P54709 1/20 0.43
FXYD2 P54710 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9527996 0.94 NOS2 (0.59) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9527723 0.92 NOS2 (0.61) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9526082 0.89 NOS2 (0.62) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9687840 0.87 NOS2 (0.61) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9528059 0.87 NOS2 (0.65) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9526158 0.85 NOS2 (0.62) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9526760 0.83 NOS2 (0.65) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9687848 0.81 ATP4A (0.43) NOS2NOS3NOS1CYP2C9ATP1A1
SCHEMBL9528053 0.81 NOS2 (0.64) NOS2NOS3NOS1CYP2E1CYP2C8
SCHEMBL9688799 0.79 NOS2 (0.50) NOS2NOS3NOS1CYP2E1CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0201575-B1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1992-08-12 EP disclosed
US-4686230-A Picoline derivative useful as gastric acid secretion inhibitors BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1987-08-11 US disclosed
EP-0201575-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM. BYK GULDEN LOMBERG CHEM FAB (DE) 1986-11-20 EP disclosed
EP-0050800-B1 CARBOXYALKYL DIPEPTIDES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1986-06-18 EP disclosed
WO-1986002646-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT M (DE) 1986-05-09 WO disclosed