Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PPID | Q08752 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484404 | 0.94 | PIN1 (0.49) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL14434253 | 0.91 | LTA4H (0.49) | PIN1ALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL3213534 | 0.89 | ALDH1A1 (0.55) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL5941081 | 0.89 | PIN1 (0.56) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL691909 | 0.88 | SMN1; SMN2 (0.56) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL22144166 | 0.87 | PIN1 (0.50) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL4433228 | 0.87 | PIN1 (0.52) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3213531 | 0.87 | PIN1 (0.52) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3211799 | 0.87 | PIN1 (0.52) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL15173708 | 0.86 | PIN1 (0.54) | PIN1ALDH1A1SMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245053-B1 | HETEROCYCLIC FUSED TRICYCLIC COMPOUNDS | ICI AMERICAS INC. (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0245053-A1 | Heterocyclic fused tricyclic compounds | ICI AMERICAS INC. (US) | 1987-11-11 | — | — | EP | disclosed |