Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28121571 | 0.81 | TP53 (0.47) | KDM4EFBP1MEN1KMT2AALDH1A1 | |
| SCHEMBL143642 | 0.78 | ALDH1A1 (0.54) | FBP1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL143643 | 0.78 | ALDH1A1 (0.54) | FBP1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14198007 | 0.78 | LCK (0.54) | KDM4ECCNB2CDK1CDK4CCNB1 | |
| SCHEMBL21852333 | 0.76 | ALDH1A1 (0.55) | KDM4ECYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL8724395 | 0.76 | ALDH1A1 (0.55) | KDM4ECYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL16601893 | 0.76 | LCK (0.52) | KDM4ECCNB2CDK1CDK4CCNB1 | |
| SCHEMBL28122190 | 0.76 | NFE2L2 (0.47) | KDM4EFBP1MEN1KMT2ALMNA | |
| SCHEMBL8040509 | 0.76 | KDM4E (0.60) | KDM4ECCNB2CDK1CDK4CCNB1 | |
| SCHEMBL1137220 | 0.74 | AKR1C3 (0.66) | KDM4ECCNB2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |