Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28729479 | 0.83 | MEN1 (0.51) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL29431832 | 0.83 | MEN1 (0.51) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL6797523 | 0.82 | MEN1 (0.63) | MEN1KMT2AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL5797626 | 0.80 | RAB9A (0.56) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9281428 | 0.80 | MAPT (0.48) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7908594 | 0.80 | LMNA (0.48) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL552157 | 0.80 | LMNA (0.51) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL2222503 | 0.80 | MEN1 (0.56) | LMNAMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL6792229 | 0.79 | MEN1 (0.59) | MEN1KMT2AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL11016312 | 0.79 | MEN1 (0.63) | LMNAMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |