Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 5/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385587 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL7970819 | 0.90 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL9879885 | 0.87 | NOS2 (0.51) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL7492660 | 0.86 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL9385569 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL7982299 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL9690656 | 0.83 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL9698262 | 0.83 | SMN1; SMN2 (0.54) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| Water SCHEMBL10396512 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT | |
| Water SCHEMBL10396513 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |