Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995354 | 0.85 | LMNA (0.71) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9698901 | 0.85 | LMNA (0.73) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL7492660 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9687041 | 0.84 | KDM4E (0.52) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9698687 | 0.84 | ALDH1A1 (0.53) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9629448 | 0.84 | LMNA (0.57) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9698262 | 0.83 | SMN1; SMN2 (0.54) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL6995967 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9629294 | 0.82 | LMNA (0.67) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL7970819 | 0.82 | KDM4E (0.51) | ALDH1A1LMNAGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |
| US-RE33833-E | Intermediates for antihistamines, antiserotonine agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-25 | — | — | US | disclosed |
| US-4820822-A | ANTIHISTAMINE, ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA (BE) | 1989-04-11 | — | — | US | disclosed |
| US-4760074-A | Novel-N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-26 | — | — | US | disclosed |
| EP-0099139-B1 | NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-11 | — | — | EP | disclosed |
| US-4556660-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-03 | — | — | US | disclosed |
| EP-0099139-A2 | Novel N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-01-25 | — | — | EP | disclosed |